Three months later, inside the Desert King conference room in early July, sitting across from a shelf displaying Slurpee cups and bottles of Stewart’s Root Beer, Hiley let out a chuckle through his surgical mask. In the end, Hiley knew there was only one way to answer Erck: “Of course, we can deliver it,” he said. And last year he had made the ill-timed decision to postpone expanding their pharmaceutical operations in favor of investing in Desert King’s booming animal-feed business. Hiley’s immediate concern was that his Chilean operation had already missed the bark-harvesting window-typically during the trees’ spring growth, between September and December. Novavax needed guarantees of 1,500 pounds of saponin now, and up to three times as much next year. It would also soon be on the short list of vaccine candidates funded by the Trump administration’s Operation Warp Speed. Novavax was on the cusp of receiving $384 million in international funding to help it produce 100 million doses of its COVID-19 vaccine for the world by the end of the year, and a billion doses by the end of 2021. And the Hileys practically had a monopoly on it.ĭuring his call with the Hileys, Erck asked if Desert King could increase their production for Novavax a hundredfold. Novavax has its own saponin-based adjuvant, called Matrix-M, and warned investors last year that their vaccines could be delayed if they failed to “secure sufficient supplies” of high-quality extract. “If you take out all the trees in one shot and deplete the source of saponin, you are in deep shit in the future,” says Garo Armen, whose company, Agenus, helped bring QS-21 to market. Everyone in the business knew the story of the Pacific yew tree, whose bark was the original source of the chemotherapy drug paclitaxel, and which was threatened by large-scale harvesting in the 1980s. Nine years ago, researchers estimated that the global supply of pharmaceutical-grade Quillaja extract was sufficient for just 6 million doses of vaccine. Food and Drug Administration, and QS-21 is one of the newest.Ī single gram of powdered QS-21 costs more than $100,000, though only about $5 worth is needed for each shot. Owing to their potential risks to human health, however, only a handful of adjuvants have been approved by the U.S. Adjuvants are compounds that boost the body’s immune reaction to a vaccine. This precious goo does many things well, and it happens to be the raw material for one of the world’s most coveted vaccine adjuvants: QS-21. Pulverized and soaked in water at the Desert King factory in Chile, the bark is transformed into a brown, bitter, bubbly fluid. The inner bark of the Chilean soapbark tree, Quillaja saponaria, is the source material for some of these saponins. And its success, Erck believed, depended on that odd ingredient in Slurpees. But like other companies around the world, Novavax had thrown its hat into the coronavirus-vaccine race. Not a seller of vaccines, mind you: The company had yet to bring one of its candidates to market. Erck is the CEO of Novavax, a Maryland-based maker of vaccines. Then, one day-April 14th, to be exact-his son told him that they had a call with Stanley Erck. “My theory of business is the only two people who need to know my name are my wife and my banker,” he told me recently. Most of us never think about these compounds, and Hiley has always liked it that way. Maybe his son, Damian, would take over.įor more than 42 years, Hiley has been a leading purveyor of certain plant-based food additives such as saponins, foaming agents used in root beer and Slurpees. California had issued its initial stay-at-home order for COVID-19, but apart from the hand sanitizer around the office, life was more or less normal. In early April, Paul Hiley was kicking back in the executive suite at Desert King International LLC, gazing out the window at the San Diego sunshine and daydreaming about his golf game.
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It represents an innovative approach that may foster new advances in psychopathology research. Cowriting can be defined as the practice in which clinicians or researchers and individuals with the lived experience of a disorder are mutually engaged in writing jointly a narrative related to the given condition. It is a co-written paper which means it is based on sharing perspectives and meanings about the experience of crisis, recovery, and the healing process. Expert by experience in this context refers to someone with firsthand knowledge of mental illness. This article is a collaboration between Helene Cæcilie Mørck, an expert by experience and professional choreographer, and Giovanni Stanghellini, a psychiatrist trained in phenomenology. The act of a form is that by which a form forms itself: To Helene Cæcilie’s otherwise disintegrated Self- and world-experience, dance operates an embodied Gestaltung which restores continuity and temporal coherence to the Self, individuality, and boundaries in space, unity, and structure in the body, attunement with other bodies in movement and at the same time delimitation with respect to them. It has been argued that most of the schizophrenic person’s efforts are directed at compensating for this disintegration – putting together and reassembling what is scattered. We find Gestaltung at work in the chiasm linking the moment of disintegration and that of reintegration in the course of schizophrenic existence. Delusional explanations, creation of art products, and dance are traced back in this paper to a process of Gestaltung – a German term that in English can be rendered as “form in formation” – the act of giving form to the experience of the formless. In her existence, this dialectic transforms her experience of disintegration (a “very bleak place”) into something “life-affirming” through choreography. Her experience shows the dialectic of disintegration and reintegration that characterizes the existence of a schizophrenic person. Choreographies have been a memory map tracing her mental state through the years. Through the act of automatic writing while in psychosis, Helene Cæcilie has transformed the bewildering world of her mind into choreography. For Helene Cæcilie, an expert by experience, dance has served as an artistic outlet for schizophrenia, allowing her to work and exist in the world. This co-written paper discusses strategies for dealing with schizophrenia. Make sure it's securely and tightly sealed.
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